Standard Care | Minimal Risk

Adapalene (DIFFERIN adapalene 1mg/g gel tube)

Adapalene risk profile, scheduling, and guidance for claims professionals and care workers . Also known as DIFFERIN adapalene 1mg/g gel tube, DIFFERIN adapalene 1mg/g cream tube, EPIDUO 0.1%/2.5% adapalene / benzoyl peroxide gel tube.

Source: TGA, FDA Updated April 2026

Adapalene (brand names: DIFFERIN adapalene 1mg/g gel tube, DIFFERIN adapalene 1mg/g cream tube, EPIDUO 0.1%/2.5% adapalene / benzoyl peroxide gel tube) is classified as Minimal risk by AllMeds. It is a S4 medication under the TGA in Australia. FDA approved in the United States. Topical retinoid for acne with minimal systemic effects and no workplace safety risk.

Key Takeaways

  • TGA Schedule: S4 in Australia
  • Risk level: Minimal (0 points)

Scheduling and Classification

Jurisdiction Classification Status
Australia (TGA) S4 Not PBS listed
United States (FDA) Rx only FDA approved

Risk Profile

Risk Level Minimal
Risk Points 0
CNS Depressant No
Respiratory Risk No

Topical retinoid for acne with minimal systemic effects and no workplace safety risk.

Regulatory and Compliance Guidance

When Adapalene appears on a claimant's medication list, claims professionals should assess whether the prescribing is appropriate for the compensable injury, whether the duration is within guidelines, and whether there are interactions with other medications on the claim.

Australia TGA / PBS / State Schemes

Classified as S4 under the Therapeutic Goods Administration (TGA).

United States FDA / CDC / State WC

FDA approved for use in the United States.

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Medical Disclaimer: This content is for informational purposes for claims professionals and care workers. It is not medical advice. Always consult a qualified healthcare professional for clinical decisions. Drug information is sourced from TGA, FDA, MHRA, PBS, NICE, and CDC databases and may not reflect the latest updates. AllMeds does not replace clinical judgement.