Immunosuppressant | Low Risk

Methotrexate (Trexject)

Methotrexate risk profile, scheduling, and guidance for claims professionals and care workers . Also known as Trexject, DBL Methotrexate, Methoblastin, Chexate, ARX-Methotrexate and 2 more.

Source: PBS, TGA Updated April 2026

Methotrexate (brand names: Trexject, DBL Methotrexate, Methoblastin, Chexate, ARX-Methotrexate and 2 more) is classified as Low risk (2 risk points) by AllMeds. It is a S4 medication under the TGA in Australia. Immunosuppressant and chemotherapy agent with potential fatigue and cognitive effects affecting workplace performance.

Key Takeaways

  • TGA Schedule: S4 in Australia
  • Risk level: Low (2 points)
  • PBS listed: Subsidised under the Australian Pharmaceutical Benefits Scheme

Scheduling and Classification

Jurisdiction Classification Status
Australia (TGA) S4 PBS listed

Risk Profile

Risk Level Low
Risk Points 2
CNS Depressant No
Respiratory Risk No

Immunosuppressant and chemotherapy agent with potential fatigue and cognitive effects affecting workplace performance.

Regulatory and Compliance Guidance

When Methotrexate appears on a claimant's medication list, claims professionals should assess whether the prescribing is appropriate for the compensable injury, whether the duration is within guidelines, and whether there are interactions with other medications on the claim.

Australia TGA / PBS / State Schemes

Classified as S4 under the Therapeutic Goods Administration (TGA).

Listed on the Pharmaceutical Benefits Scheme (PBS) for subsidised prescribing.

Need to assess this medication across your caseload?

Run a full risk assessment including Methotrexate interactions and compliance checks.

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Medical Disclaimer: This content is for informational purposes for claims professionals and care workers. It is not medical advice. Always consult a qualified healthcare professional for clinical decisions. Drug information is sourced from TGA, FDA, MHRA, PBS, NICE, and CDC databases and may not reflect the latest updates. AllMeds does not replace clinical judgement.