S4 | Prescription Only

What Schedule Is Propofol?

Propofol scheduling and classification across Australia, United States, and international jurisdictions. Also known as DIPRIVAN propofol 500mg/50mL injection syringe, DIPRIVAN propofol 1g/100mL injection vial, DIPRIVAN propofol 500mg/50mL injection vial.

S4 in Australia Source: TGA, FDA Updated April 2026

Propofol (DIPRIVAN propofol 500mg/50mL injection syringe) is classified as S4 (Prescription Only Medicine - requires a valid prescription from an authorised prescriber) under the Therapeutic Goods Administration (TGA) in Australia. It is FDA approved in the United States.

Key Takeaways

  • Australia (TGA): S4 - Prescription Only Medicine - requires a valid prescription from an authorised prescriber
  • United States (FDA): Approved (Rx only)
  • Risk level: Moderate (7 points)

Scheduling by Jurisdiction

Jurisdiction Regulatory Body Classification Status
Australia TGA (Therapeutic Goods Administration) S4 Not PBS listed
United States FDA / DEA Rx only (not DEA scheduled) FDA approved

What S4 Means for Propofol

Propofol is classified as S4 under the TGA Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP). Prescription Only Medicine - requires a valid prescription from an authorised prescriber.

Schedule 4 Prescribing Requirements

  • Prescribing: Requires a valid prescription from a registered medical practitioner, dentist, or authorised prescriber.
  • Dispensing: Must be dispensed by a pharmacist against a valid prescription.
  • Repeats: Repeat prescriptions are permitted as specified by the prescriber.

Claims and Workers Compensation Implications

When Propofol (S4) appears on a claimant's medication list, the scheduling classification affects how claims professionals should assess and manage the claim.

As a Schedule 4 prescription medicine, claims professionals should verify that Propofol is being prescribed for the compensable injury and review duration against clinical guidelines. As a CNS depressant, it may affect work capacity and return-to-work timelines.

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Related Resources

Medical Disclaimer: This content is for informational purposes for claims professionals and care workers. It is not medical advice. Always consult a qualified healthcare professional for clinical decisions. Drug information is sourced from TGA, FDA, MHRA, PBS, NICE, and CDC databases and may not reflect the latest updates. AllMeds does not replace clinical judgement.