Moderate Risk | Side Effects Guide

Esketamine (nasal spray) Side Effects

Side effects of Esketamine (nasal spray) (Spravato) that impact work capacity, driving, and recovery for claims professionals, support workers, and care managers. Also known as Spravato.

Source: AllMeds_Curated Updated April 2026

Esketamine (nasal spray) (Spravato) is classified as Moderate risk by AllMeds. It is a CNS depressant that can cause drowsiness, impaired coordination, and reduced cognitive function, directly affecting work capacity and return-to-work timelines. For claims professionals, the side effects of Esketamine (nasal spray) can impact work capacity, driving fitness, and recovery timelines.

Key Takeaways

  • Risk level: Moderate (5 points)
  • CNS depressant: Causes sedation, impairs driving, affects cognitive function
  • Claims action: Assess work capacity impact, check for dangerous interactions, review duration against guidelines

Side Effects That Affect Work Capacity

These side effects of Esketamine (nasal spray) can directly impact a claimant's ability to work, drive, and perform daily activities:

  • Drowsiness and sedation
  • Impaired concentration and cognitive function
  • Slowed reaction time
  • Impaired coordination and balance

Work capacity certificates should reflect any medication-related restrictions. For safety-sensitive roles (driving, operating machinery, working at heights), these effects may require modified duties or temporary stand-down.

Serious Safety Concerns

These side effects require clinical monitoring and may affect claim management decisions:

  • Review product information for complete safety profile

Flags for Claims Professionals

  • CNS depressant effects may delay return to work, particularly in safety-sensitive roles

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Related Resources

Medical Disclaimer: This content is for informational purposes for claims professionals and care workers. It is not medical advice. Always consult a qualified healthcare professional for clinical decisions. Drug information is sourced from TGA, FDA, MHRA, PBS, NICE, and CDC databases and may not reflect the latest updates. AllMeds does not replace clinical judgement.