Irbesartan + hydrochlorothiazide (Avapro HCT 300/25)
What to know about Irbesartan + hydrochlorothiazide — also sold as Avapro HCT 300/25, Karvezide 300/25, Irbesartan/HCT Sandoz, APO-Irbesartan HCTZ, AVSARTAN HCT 300/25 and 12 more: uses, side effects, interactions, and safety considerations for people taking it or caring for someone who is.
Irbesartan + hydrochlorothiazide (brand names: Avapro HCT 300/25, Karvezide 300/25, Irbesartan/HCT Sandoz, APO-Irbesartan HCTZ, AVSARTAN HCT 300/25 and 12 more) is classified as Low risk (1 risk points) by AllMeds. It is a S4 medication under the TGA in Australia. ARB-diuretic combination with low occupational risk.
Key Takeaways
- TGA Schedule: S4 in Australia
- Risk level: Low (1 points)
- PBS listed: Subsidised under the Australian Pharmaceutical Benefits Scheme
Scheduling and Classification
| Jurisdiction | Classification | Status |
|---|---|---|
| Australia (TGA) | S4 | PBS listed |
Risk Profile
ARB-diuretic combination with low occupational risk.
How Irbesartan + hydrochlorothiazide is regulated
Irbesartan + hydrochlorothiazide is overseen by medicines regulators in each country. The rules below explain how it's scheduled, what oversight applies, and what to discuss with your doctor or pharmacist before starting, changing, or stopping this medication.
Australia TGA / PBS / State Schemes
Classified as S4 under the Therapeutic Goods Administration (TGA).
Listed on the Pharmaceutical Benefits Scheme (PBS) for subsidised prescribing.
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Important: This page is general health information, not personal medical advice. If you have questions about your medication — including starting it, stopping it, changing the dose, or combining it with something else — speak with your doctor or pharmacist. For an emergency or suspected overdose, call your local emergency number or poison information service immediately. Information is drawn from regulator and clinical guideline sources (TGA, FDA, MHRA, NICE, PBS, CDC); see our methodology for details.